Multi-scale MRI spectrum detects differences in myelin integrity between MS lesion types.

نویسندگان

  • Yunyan Zhang
  • Laura Jonkman
  • Antoine Klauser
  • Frederik Barkhof
  • V Wee Yong
  • Luanne M Metz
  • Jeroen Jg Geurts
چکیده

BACKGROUND Lesions with different extents of myelin pathology are found at autopsy in multiple sclerosis (MS), but the differences are not discernible in magnetic resonance imaging (MRI). OBJECTIVE To determine whether analysis of the local spectrum in MRI is sensitive to lesion differences in myelin integrity. METHODS We imaged fresh brain slices from 21 MS patients using 1.5T scanners. White matter lesions were identified in T2-weighted MRI, matched to corresponding specimens, and then classified into five categories in histology: pre-active (intact myelin); active, chronic active, chronic inactive (complete demyelination); and remyelinated lesions. Voxel-based frequency spectrum was calculated using T2-weighted MRI to characterize lesion structure (image texture). RESULTS MRI texture heterogeneity resulting from all spectral scales was greater in completely demyelinated lesions than in myelin-preserved lesions (p = 0.02) and normal-appearing white matter (p < 0.01). Moreover, the spectral distribution pattern over low-frequency scales differentiated demyelinated lesions from remyelinated and pre-active lesions (p < 0.01), where different lesion types also showed distinct texture scales. CONCLUSION Using multi-scale spectral analysis, it may be possible for standard MRI to evaluate myelin integrity in MS lesions. This can be critical for monitoring disease activity and assessing remyelination therapies for MS patients.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders

Myelin-Oligodendrocyte Glycoprotein (MOG) is an adhesive molecule responsible for myelin sheath structural integrity and maintenance. Patients with spectrum of inflammatory demyelinating disease particularly in central nervous system are reported to have antibodies against this protein. Diseases such as multiple sclerosis, clinically isolated syndrome, neuro-myelitis optica (NMO) spectrum disor...

متن کامل

Deficient MWF mapping in multiple sclerosis using 3D whole-brain multi-component relaxation MRI

Recent multiple sclerosis (MS) MRI research has highlighted the need to move beyond the lesion-centric view and to develop and validate new MR imaging strategies that quantify the invisible burden of disease in the brain and establish much more sensitive and specific surrogate markers of clinical disability. One of the most promising of such measures is myelin-selective MRI that allows the acqu...

متن کامل

Early MRI changes in a mouse model of multiple sclerosis are predictive of severe inflammatory tissue damage.

MRI is routinely used for in vivo detection of multiple sclerosis (MS) lesions. Histopathological correlates of MRI signal alterations are still poorly defined. In the present study, we describe a mouse model of MS presenting with inflammatory brain lesions. During the acute disease phase, two independent lesion patterns were identified by T1- and T2-weighted high-resolution 3D MRI: lesions wit...

متن کامل

Neuroimaging: Evaluating the Clinical Course and Pathology of Ms*

Conventional magnetic resonance imaging (MRI) techniques are important tools in the diagnosis and management of patients with multiple sclerosis (MS), but they reveal only a small part of the overall disease process. Lesion burden on T2weighted MRI correlates to some extent with disability during the early stages of the disease, but is less sensitive to increasing disability among patients with...

متن کامل

Age independently affects myelin integrity as detected by magnetization transfer magnetic resonance imaging in multiple sclerosis

BACKGROUND Multiple sclerosis (MS) is a heterogeneous disorder with a progressive course that is difficult to predict on a case-by-case basis. Natural history studies of MS have demonstrated that age influences clinical progression independent of disease duration. OBJECTIVE To determine whether age would be associated with greater CNS injury as detected by magnetization transfer MRI. MATERI...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Multiple sclerosis

دوره 22 12  شماره 

صفحات  -

تاریخ انتشار 2016